When widespread in a tree fireblight can be difficult if not impossible to control, best if stopped early. The bacteria is spread by two means, infected pollen during bloom and physical injury such as pruning during growing season.
Bacteria is not active in dormant season so this is best time to remove large infected limbs. When Summer pruning newly infected shoots use the "ugly stub" technique. Make a cut 6" to 10" below infection, cut stems should be sprayed with disinfectant too remove stub when dormant. Bleach solution is effective but corrodes tools and stains clothes I prefer lysol.Dipping tools is time consuming I use a felco lopper with built in spray nozzle and pressurized can to automatically apply between each cut. I attached a picture.Also avoid anything which stimulates a flush of new growth such as fertilizing or heavy pruning,new shoots are most susceptible. Good luck