It depends on what you like. I've noticed neopro tends to harden (less supple) and get a little thin once it's fully stretched. It probably would be better in natural crotches until you get some picks in it... the picks definitely get worse once they're started. It's tough rope though.
Tachyon is going to feel more like Fly though, neopro feels pretty different. I would want to use a friction saver with Tachyon though... not necessarily all the time or anything but just in general.
Your body is going to thank you if you use a friction saver as much as possible.