Concur on the sidewall vs tread plug application. Can't recall if there's any betterness internal patch vs plug. Definitely there's a big durability difference between bicycle glue/materials and automotive. Way back I picked up a nail east of Whistler right at a scenic lake turnout. There was a European guy camping/touring out of his car who informed me a group of bicyclists were passing by. They gave me a patch and some glue. Young and ill prepared I thought canned fix flat would work. nope. So I hoisted the bike over a log, pulled the rear wheel, pulled the tube, patch it, reassemble, Bob's yer uncle. About 2 or 300 km down the highway patch blew off same day. Local automotive shop stayed open late and put an automotive patch on. Over a log in highway quickie mart parking lot for #2, luggage in back room ! Hitched rides to nearby town/shop I think with the whole back wheel IIRC. Got me back to Toronto plus more service beyond. That might have been the same day I got caught out riding mountain twisties in the dark by headlight in a rain storm trying to make Calgary.
Ahh

the distraction from the current news cycle