The test for Lyme disease is a blood test. In the later stages, the test looks for antibodies in the blood. Lyme disease is actually a "great imitator"; it can mimic many other conditions, so the history of a tick bite and the symptoms that follow is the best way to diagnose. I had Lyme disease this past summer and because of my clinical knowledge of the disease I was well aware that it was Lyme, however it could easily have been overlooked. I removed the deer tick and within a few days developed a rash that was similar to a mild case of hives. Within 2 weeks I had a severe headache that lasted for 5 days before I began antibiotics, and I also became extremely fatigued (slept for 16 hours the day I began antibiotics) The difficulty with diagnosis is that everyone's symptoms can be different and there are many false negatives with the blood work. Therefore, it is very important that you see a physician who is very familiar with Lyme. Early treatment involves a 30-45 day course of antibiotics, however the longer the bacteria is in your system, the longer and more difficult treatment is.